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The idea of the TC2N project was initially evoked in September 2008 when research teams from Portsmouth University joined the LARC-Neuroscience Network. The LARC-Neuroscience Network was initially created in 1997 by 4 laboratories from Lille, Amiens, Rouen and Caen (LARC) to develop research and teaching in the Neuroscience field. Today, this network federates 40 laboratories from Nijmegen to Brest, including some research teams in Portsmouth (http://larc-neurosciences.univ-rouen.fr). With the Interreg support, we would like to stimulate the cooperation between some of the teams of this network and to associate new teams from UK (Exeter, Brighton), Belgium (Gent) and Netherland (Rotterdam) to the network. The cooperation will involve the development of protocols together, the establishment of collaborative research projects (focused on 5 research themes) and the exchange of staff. Our cooperation will be supported by 5 Core Facilities located in different cities that we want to share. We also want to set up new activities such as trainings for academia and SME, communication to the lay public or traveling support to students who want to go in another Laboratory or Core Facility. Altogether, the TC2N project formally brings together over 130 people highly motivated to conduct an active cross border cooperation.