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Pathophysiology, Autoimmunity, Neuromuscular diseases and regenerative THERapies

U1234 (PANTHER)

Research team

Inserm, Université de Rouen

Olivier BOYER
olivier.boyer@chu-rouen.fr

Research unit 1234 Inserm/University
Faculty of Medicine and Pharmacy
22 Boulevard Gambetta

76183
Rouen
http://irib.univ-rouen.fr/index.php?info=entites&id=15

Research interest:

The U1234 research unit (formerly U905) is dedicated to the study of inflammatory and autoimmune diseases of the neuromuscular system, and to the development of cell/gene therapy strategies for acquired or inherited muscle diseases, autoimmune diseases and corneal diseases. For this, the laboratory develops a basic research on the mechanisms regulating the immune system in health and disease (including neuropeptides and extracellular nucleotides), a translational research including clinical trials and monitoring of antigen-specific responses in autoimmune diseases. With support of the Department of Immunology, the Laboratory of Biotherapy and other clinical departments of Rouen University Hospital, U1234 studies the pathophysiological mechanisms of autoimmunity through murine models of autoimmune myopathies and multiple sclerosis, and the development of clinical trials.

Collaborations that have resulted in joint publications with other teams of the network:

Denis VIVIEN / UMR-S U1237
Bruno GONZALEZ / U1245 (Dir T Frebourg)
Youssef ANOUAR / U1239 - Equipe Génomique fonctionnelle et physiopathologie neuronale et neuroendocrine
David VAUDRY / U1239 - Differenciation et Communication Neuronale et Neuroendocrine
Pascal COSETTE / David VAUDRY / PISSARO
Jean-Claude DO REGO / SCAC
Pierre DECHELOTTE / INSERM UMR 1073
Jean-Paul MARIE / EA 3830

Ongoing collaborations which have not yet conducted to joint publications:

Patrick DALLEMAGNE / CERMN EA 4258 - FR CNRS 3038 INC3M - SF 4206 ICORE - Tremplin Carnot I2C
David VAUDRY / U1239 - Differenciation et Communication Neuronale et Neuroendocrine

Main publications over the last few years:

27379096

Simon JP, Marie I, Jouen F, Boyer O and Martinet JAutoimmune Myopathies: Where Do We Stand. Front Immunol 2016, 7234.

27357191

Abad C,, Jayaram B, Becquet L, Wang Y, O'Dorisio MS, Waschek JA and Tan YV,VPAC1 receptor (Vipr1)-deficient mice exhibit ameliorated experimental autoimmune encephalomyelitis, with specific deficits in the effector stage. J Neuroinflammation 2016, 13169.

26265250

Hardet R,, Chevalier B,, Dupaty L,, Naïmi Y,, Riou G,, Drouot L,, Jean L,, Salvetti A,,,, Boyer O,, and Adriouch S,Oral-tolerization Prevents Immune Responses and Improves Transgene Persistence Following Gene Transfer Mediated by Adeno-associated Viral Vector. Mol Ther 2016, 2487-95.

26074381

Kipfer S, Frigerio S, Hench J, Aussy A and Boyer OImmune-mediated necrotising myopathy linked to statin use. Lancet 2015, 386e26.

25753532

Teege S, Hann A, Miksiewicz M, MacMillan C, Rissiek B, Buck F, Menzel S, Nissen M, Bannas P, Haag F, Boyer O, Seman M, Adriouch S and Koch-Nolte FTuning IL-2 signaling by ADP-ribosylation of CD25. Sci Rep 2015, 58959.

25579751

Benveniste O, Stenzel W, Hilton-Jones D, Sandri M, Boyer O and van Engelen BGAmyloid deposits and inflammatory infiltrates in sporadic inclusion body myositis: the inflammatory egg comes before the degenerative chicken. Acta Neuropathol 2015, 129611-24.

25565635

Bisson A, Le Corre S, Joly-Helas G, Chambon P, Demoulins L, Jean L, Adriouch S, Drouot L, Giverne C, Roussel F, Jacquot S, Doucet C, Michot F, Lamacz M, Frébourg T, Flaman JM and Boyer OChromosomal instability but lack of transformation in human myoblast preparations. Cell Transplant 2014, 231475-87.

25564520

Hofman P, Cherfils-Vicini J, Bazin M, Ilie M, Juhel T, Hébuterne X, Gilson E, Schmid-Alliana A, Boyer O, Adriouch S and Vouret-Craviari VGenetic and pharmacological inactivation of the purinergic P2RX7 receptor dampens inflammation but increases tumor incidence in a mouse model of colitis-associated cancer. Cancer Res 2015, 75835-45.

25305591

Tan YV, Abad C, Wang Y, Lopez R and Waschek JAVPAC2 (vasoactive intestinal peptide receptor type 2) receptor deficient mice develop exacerbated experimental autoimmune encephalomyelitis with increased Th1/Th17 and reduced Th2/Treg responses. Brain Behav Immun 2015, 44167-75.

24797170

Allenbach Y, Drouot L, Rigolet A, Charuel JL, Jouen F, Romero NB, Maisonobe T, Dubourg O, Behin A, Laforet P, Stojkovic T, Eymard B, Costedoat-Chalumeau N, Campana-Salort E, Tournadre A, Musset L, Bader-Meunier B, Kone-Paut I, Sibilia J, Servais L, Fain OAnti-HMGCR autoantibodies in European patients with autoimmune necrotizing myopathies: inconstant exposure to statin. Medicine (Baltimore) 2014, 93150-7.

24484965

Drouot L, Allenbach Y, Jouen F, Charuel JL, Martinet J, Meyer A, Hinschberger O, Bader-Meunier B, Kone-Paut I, Campana-Salort E, Eymard B, Tournadre A, Musset L, Sibilia J, Marie I, Benveniste O and Boyer O; French Myositis Network [CN]Exploring necrotizing autoimmune myopathies with a novel immunoassay for anti-3-hydroxy-3-methyl-glutaryl-CoA reductase autoantibodies. Arthritis Res Ther 2014, 16R39.

23850081

Fréret M, Drouot L, Obry A, Ahmed-Lacheheb S, Dauly C, Adriouch S, Cosette P, Authier FJ and Boyer OOverexpression of MHC class I in muscle of lymphocyte-deficient mice causes a severe myopathy with induction of the unfolded protein response. Am J Pathol 2013, 183893-904.

23638158

Mayeur A, Duclos C, Honoré A, Gauberti M, Drouot L, do Rego JC, Bon-Mardion N, Jean L, Vérin E, Emery E, Lemarchant S, Vivien D, Boyer O, Marie JP and Guérout NPotential of olfactory ensheathing cells from different sources for spinal cord repair. PLoS One 2013, 8e62860.

22674045

Liao H, Franck E, Fréret M, Adriouch S, Baba-Amer Y, Authier FJ, Boyer O and Gherardi RKMyoinjury transiently activates muscle antigen-specific CD8+ T cells in lymph nodes in a mouse model. Arthritis Rheum 2012, 643441-51.

22161947

Honoré A, Le Corre S, Derambure C, Normand R, Duclos C, Boyer O, Marie JP and Guérout NIsolation, characterization, and genetic profiling of subpopulations of olfactory ensheathing cells from the olfactory bulb. Glia 2012, 60404-13.

21400483

Benveniste O, Drouot L, Jouen F, Charuel JL, Bloch-Queyrat C, Behin A, Amoura Z, Marie I, Guiguet M, Eymard B, Gilbert D, Tron F, Herson S, Musset L and Boyer OCorrelation of anti-signal recognition particle autoantibody levels with creatine kinase activity in patients with necrotizing myopathy. Arthritis Rheum 2011, 631961-71.

21305567

Guérout N, Duclos C, Drouot L, Abramovici O, Bon-Mardion N, Lacoume Y, Jean L, Boyer O and Marie JPTransplantation of olfactory ensheathing cells promotes axonal regeneration and functional recovery of peripheral nerve lesion in rats. Muscle Nerve 2011, 43543-51.

21168497

Paviot A, Guérout N, Bon-Mardion N, Duclos C, Jean L, Boyer O and Marie JPEfficiency of laryngeal motor nerve repair is greater with bulbar than with mucosal olfactory ensheathing cells. Neurobiol Dis 2011, 41688-94.

20978211

Abad C, Tan YV, Lopez R, Nobuta H, Dong H, Phan P, Feng JM, Campagnoni AT and Waschek JAVasoactive intestinal peptide loss leads to impaired CNS parenchymal T-cell infiltration and resistance to experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 2010, 10719555-60.

20975043

Hubert S, Rissiek B, Klages K, Huehn J, Sparwasser T, Haag F, Koch-Nolte F, Boyer O, Seman M and Adriouch SExtracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway. J Exp Med 2010, 2072561-8.

19190179

Tan YV, Abad C, Lopez R, Dong H, Liu S, Lee A, Gomariz RP, Leceta J and Waschek JAPituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 2009, 1062012-7.

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