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Alzheimer & Tauopathies

U1172

Research team

Université de Lille

Luc BUEE
Contact for the network: David Blum

Centre de Recherche Jean-Pierre Aubert
Place de Verdun
59045
Lille
http://lucbuee.fr/

Research interest:

L'équipe "Alzheimer & Tauopathies" s'intéresse aux mécanismes physiopathologiques de la maladie d'Alzheimer et de pathologies apparentées appelées Tauopathies. L'équipe aborde ces problématiques en analysant le cerveau humain normal et pathologique. Nous développons également des modèles expérimentaux des Tauopathies afin d'identifier de potentielles cibles diagnostiques et thérapeutiques.


Neurofibrillary degeneration in Alzheimer brain: immunohistochemistry with an anti-pTau

Key words: Adenosine, Alzheimer, Epigenomics, Experimental models, Neurobiology, Tau, viral vectors

Collaborations that have resulted in joint publications with other teams of the network:

Patrick DALLEMAGNE / CERMN EA 4258 - FR CNRS 3038 INC3M - SF 4206 ICORE - Tremplin Carnot I2C
Régis BORDET / INSERM U1171
Vincent PREVOT / U1172

Main publications over the last few years:

27818384

Laurent C, Dorothée G,, Hunot S,,,, Martin E,,,, Monnet Y,,,, Duchamp M,, Dong Y,, Légeron FP,,,, Leboucher A, Burnouf S, Faivre E, Carvalho K, Caillierez R, Zommer N, Demeyer D, Jouy N,, Sazdovitch V,,, Schraen-Maschke S, Delarasse Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy. Brain 2017, 140184-200.

27809932

Tardivel M, Bégard S, Bousset L, Dujardin S,, Coens A, Melki R, Buée L, and Colin M,Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies. Acta Neuropathol Commun 2016, 4117.

27709663

Huin V, Deramecourt V, Caparros-Lefebvre D, Maurage CA, Duyckaerts C, Kovari E, Pasquier F, Buée-Scherrer V, Labreuche J, Behal H, Buée L, Dhaenens CM and Sablonnière BThe MAPT gene is differentially methylated in the progressive supranuclear palsy brain. Mov Disord 2016, 311883-1890.

27605042

Mansuroglu Z, Benhelli-Mokrani H, Marcato V, Sultan A, Violet M, Chauderlier A, Delattre L, Loyens A, Talahari S, Bégard S, Nesslany F, Colin M, Souès S, Lefebvre B, Buée L, Galas MC and Bonnefoy ELoss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin. Sci Rep 2016, 633047.

27510168

Batalha VL,, Ferreira DG,,, Coelho JE, Valadas JS, Gomes R,, Temido-Ferreira M, Shmidt T, Baqi Y,, Buée L, Müller CE, Hamdane M, Outeiro TF,,, Bader M,,, Meijsing SH, Sadri-Vakili G, Blum D and Lopes LVThe caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function. Sci Rep 2016, 631493.

27435172

Papegaey A, Eddarkaoui S, Deramecourt V, Fernandez-Gomez FJ, Pantano P, Obriot H, Machala C, Anquetil V,,,,, Camuzat A,,,,, Brice A,,,,, Maurage CA, Le Ber I,,,,, Duyckaerts C,,,,, Buée L, Sergeant N and Buée-Scherrer V,,Reduced Tau protein expression is associated with frontotemporal degeneration with progranulin mutation. Acta Neuropathol Commun 2016, 474.

27230293

Domise M, Didier S, Marinangeli C, Zhao H, Chandakkar P, Buée L, Viollet B,,, Davies P, Marambaud P and Vingtdeux VAMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo. Sci Rep 2016, 626758.

27113998

Dourlen P,,, Fernandez-Gomez FJ,,, Dupont C,,, Grenier-Boley B,,, Bellenguez C,,, Obriot H,,, Caillierez R,,, Sottejeau Y,,, Chapuis J,,, Bretteville A,,, Abdelfettah F,,, Delay C,,, Malmanche N,,, Soininen H, Hiltunen M,, Galas MC,,, Amouyel P,,,, SergeaFunctional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology. Mol Psychiatry 2016

26511387

Marciniak E,,, Faivre E,,, Dutar P, Alves Pires C,,, Demeyer D,,, Caillierez R,,, Laloux C,, Buée L,,, Blum D,, and Humez S,,The Chemokine MIP-1α/CCL3 impairs mouse hippocampal synaptic transmission, plasticity and memory. Sci Rep 2015, 515862.

26385829

Violet M, Chauderlier A, Delattre L, Tardivel M, Chouala MS, Sultan A, Marciniak E, Humez S, Binder L, Kayed R, Lefebvre B, Bonnefoy E, Buée L and Galas MCPrefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo. Neurobiol Dis 2015, 82540-51.

26358780

Burlot MA, Braudeau J, Michaelsen-Preusse K, Potier B, Ayciriex S, Varin J, Gautier B, Djelti F, Audrain M, Dauphinot L, Fernandez-Gomez FJ, Caillierez R, Laprévote O, Bièche I, Auzeil N, Potier MC, Dutar P, Korte M, Buée Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology. Hum Mol Genet 2015, 245965-76.

26354981

Caparros-Lefebvre D, Golbe LI, Deramecourt V, Maurage CA, Huin V, Buée-Scherrer V, Obriot H, Sablonnière B, Caparros F, Buée L and Lees AJA geographical cluster of progressive supranuclear palsy in northern France. Neurology 2015, 851293-300.

25974414

Derisbourg M, Leghay C, Chiappetta G, Fernandez-Gomez FJ, Laurent C, Demeyer D, Carrier S, Buée-Scherrer V, Blum D, Vinh J, Sergeant N, Verdier Y, Buée L and Hamdane MRole of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms. Sci Rep 2015, 59659.

25611616

Melnyk P,,, Vingtdeux V, Burlet S, Eddarkaoui S, Grosjean ME, Larchanché PE,, Hochart G,,, Sergheraert C, Estrella C, Barrier M, Poix V, Plancq P, Lannoo C, Hamdane M, Delacourte A, Verwaerde P, Buée L and Sergeant NChloroquine and chloroquinoline derivatives as models for the design of modulators of amyloid Peptide precursor metabolism. ACS Chem Neurosci 2015, 6559-69.

25450226

Laurent C,, Burnouf S,, Ferry B, Batalha VL, Coelho JE, Baqi Y,, Malik E, Mariciniak E,, Parrot S,, Van der Jeugd A, Faivre E,, Flaten V,, Ledent C, D'Hooge R, Sergeant N,,, Hamdane M,,, Humez S,, Müller CE, Lopes LV, Buée L,, andA2A adenosine receptor deletion is protective in a mouse model of Tauopathy. Mol Psychiatry 2016, 2197-107.

25143394

Blum D, Herrera F, Francelle L, Mendes T, Basquin M, Obriot H, Demeyer D, Sergeant N, Gerhardt E, Brouillet E, Buée L and Outeiro TFMutant huntingtin alters Tau phosphorylation and subcellular distribution. Hum Mol Genet 2015, 2476-85.

24971751

Dujardin S, Bégard S, Caillierez R, Lachaud C, Delattre L, Carrier S, Loyens A, Galas MC, Bousset L, Melki R, Aurégan G, Hantraye P, Brouillet E, Buée L and Colin MEctosomes: a new mechanism for non-exosomal secretion of tau protein. PLoS One 2014, 9e100760.

24780254

Laurent C, Eddarkaoui S, Derisbourg M, Leboucher A, Demeyer D, Carrier S, Schneider M, Hamdane M, Müller CE, Buée L and Blum DBeneficial effects of caffeine in a transgenic model of Alzheimer's disease-like tau pathology. Neurobiol Aging 2014, 352079-90.

24672431

Violet M, Delattre L, Tardivel M, Sultan A, Chauderlier A, Caillierez R, Talahari S, Nesslany F, Lefebvre B, Bonnefoy E, Buée L and Galas MCA major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions. Front Cell Neurosci 2014, 884.

24479894

Dujardin S, Lécolle K, Caillierez R, Bégard S, Zommer N, Lachaud C, Carrier S, Dufour N, Aurégan G, Winderickx J, Hantraye P, Déglon N, Colin M and Buée LNeuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies. Acta Neuropathol Commun 2014, 214.

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