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Lymphocyte regulation and tolerance

UMRS 1064/ITUN-Centre de Recherche en Transplantation et en Immunologie

Research team

Inserm

Arnaud NICOT (Team leaders: S.Brouard & D.Laplaud)
Contact for the network: Arnaud NICOT

30 Bd Jean Monnet
44093
Nantes
http://www.itun.nantes.inserm.fr/index.php/team-4/

Research interest:

The team 4 of CRTI addresses questions related to T and B lymphocytes in transplantation and in multiple sclerosis (MS), with a basic and translational approach, thanks to the bio-collections and databases. Using state-of art single immune cell analysis, we are defining the phenotype of these lymphocyte populations from MS patients to better delineate their specificities and pathogenic role. As recent data suggest an important role of focal inflammation and reactive glia in white matter autoimmune pathology, we are applying LCM to white matter sections to better analyze the molecular profile of in situ reactive astrocytes in the context of MS and its animal models.


Immune cells (CD45high, red) attracted by CCL2 expressing white matter astrocytes (green). From PMID 20404154.

Key words: Lymphocytes, Glia, multiple sclerosis, neuroinflammation, steroids, FACS, Laser Capture Microdissection

Collaborations that have resulted in joint publications with other teams of the network:

David VAUDRY / PRIMACEN

Ongoing collaborations which have not yet conducted to joint publications:

Thierry CHARLIER / IRSET INSERM U1085/ Unversité de Rennes 1

Main publications over the last few years:

27050759

Salou M, Nicol B, Garcia A, Baron D, Michel L, Elong-Ngono A, Hulin P, Nedellec S, Jacq-Foucher M, Le Frère F, Jousset N, Bourreille A, Wiertlewski S, Soulillou JP, Brouard S, Nicot AB, Degauque N and Laplaud DANeuropathologic, phenotypic and functional analyses of Mucosal Associated Invariant T cells in Multiple Sclerosis. Clin Immunol 2016, 1661-11.

26635816

Salou M, Nicol B, Garcia A and Laplaud DAInvolvement of CD8(+) T Cells in Multiple Sclerosis. Front Immunol 2015, 6604.

26212105

Louveau A, Nerrière-Daguin V, Vanhove B, Naveilhan P,, Neunlist M, Nicot A and Boudin H,Targeting the CD80/CD86 costimulatory pathway with CTLA4-Ig directs microglia toward a repair phenotype and promotes axonal outgrowth. Glia 2015, 632298-312.

26141738

Guillot F,, Garcia A,, Salou M,, Brouard S,,, Laplaud DA,, and Nicot AB,Transcript analysis of laser capture microdissected white matter astrocytes and higher phenol sulfotransferase 1A1 expression during autoimmune neuroinflammation. J Neuroinflammation 2015, 12130.

26135706

Le Page E, Veillard D, Laplaud DA, Hamonic S, Wardi R, Lebrun C, Zagnoli F, Wiertlewski S, Deburghgraeve V, Coustans M and Edan G; COPOUSEP investigators; West Network for Excellence in NeuroscienceOral versus intravenous high-dose methylprednisolone for treatment of relapses in patients with multiple sclerosis (COPOUSEP): a randomised, controlled, double-blind, non-inferiority trial. Lancet 2015, 386974-81.

26125037

Salou M, Garcia A, Michel L, Gainche-Salmon A, Loussouarn D, Nicol B, Guillot F, Hulin P, Nedellec S, Baron D, Ramstein G, Soulillou JP, Brouard S, Nicot AB, Degauque N and Laplaud DAExpanded CD8 T-cell sharing between periphery and CNS in multiple sclerosis. Ann Clin Transl Neurol 2015, 2609-22.

26090495

Elong Ngono A, Lepetit M, Reindl M, Garcia A, Guillot F, Genty A, Chesneau M, Salou M, Michel L, Lefrere F, Schanda K, Imbert-Marcille BM, Degauque N, Nicot A, Brouard S, Laplaud DA and Soulillou JPDecreased Frequency of Circulating Myelin Oligodendrocyte Glycoprotein B Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis. J Immunol Res 2015, 2015673503.

25813101

Nicol B, Salou M, Laplaud DA and Wekerle HThe autoimmune concept of multiple sclerosis. Presse Med 2015, 44e103-12.

24440641

Elkabes S and Nicot ABSex steroids and neuroprotection in spinal cord injury: a review of preclinical investigations. Exp Neurol 2014, 25928-37.

22281016

Gourdain P, Ballerini C, Nicot AB and Carnaud CExacerbation of experimental autoimmune encephalomyelitis in prion protein (PrPc)-null mice: evidence for a critical role of the central nervous system. J Neuroinflammation 2012, 925.

20648642

Le Dréau G, Kular L, Nicot AB, Calmel C, Melik-Parsadaniantz S, Kitabgi P, Laurent M and Martinerie CNOV/CCN3 upregulates CCL2 and CXCL1 expression in astrocytes through beta1 and beta5 integrins. Glia 2010, 581510-21.

20489728

Kurnellas MP, Li H, Jain MR, Giraud SN, Nicot AB, Ratnayake A, Heary RF and Elkabes SReduced expression of plasma membrane calcium ATPase 2 and collapsin response mediator protein 1 promotes death of spinal cord neurons. Cell Death Differ 2010, 171501-10.

20404154

Giraud SN, Caron CM, Pham-Dinh D, Kitabgi P and Nicot ABEstradiol inhibits ongoing autoimmune neuroinflammation and NFkappaB-dependent CCL2 expression in reactive astrocytes. Proc Natl Acad Sci U S A 2010, 1078416-21.

19286457

Le Dréau G, Nicot A, Bénard M, Thibout H, Vaudry D, Martinerie C and Laurent MNOV/CCN3 promotes maturation of cerebellar granule neuron precursors. Mol Cell Neurosci 2010, 4360-71.

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