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Institute of Biomedical and Biomolecular Science

IBBS

Research team

University of Portsmouth, UK

Darek GORECKI
darek.gorecki@port.ac.uk

School of Pharmacy and Biomedical Sciences
St Michael Bld.
White Swan Road

PO1 2DT,
Portsmouth
http://www.port.ac.uk/research/ibbs/cellularandmolecularmedicine/molecularmedicine/


Dystrophin-associated protein complex interactions at the gliovascular interface

Key words: Duchenne muscular dystrophy, dystrophin, dystrobrevin, purinergic receptors, gene therapy

Collaborations that have resulted in joint publications with other teams of the network:

Frédéric LANCIEN / UMR 6539
David VAUDRY / U1239 - Differenciation et Communication Neuronale et Neuroendocrine
David VAUDRY / PRIMACEN
Jean-Claude DO REGO / SCAC

Ongoing collaborations which have not yet conducted to joint publications:

Myriam BERNAUDIN / ISTCT- FRE2001
Helene CASTEL / U1239 - DC2N
Jean-Claude DO REGO / SCAC

Main publications over the last few years:

26461208

Sinadinos A, Young CN, Al-Khalidi R, Teti A, Kalinski P, Mohamad S, Floriot L, Henry T, Tozzi G, Jiang T, Wurtz O, Lefebvre A, Shugay M, Tong J, Vaudry D, Arkle S, doRego JC and Górecki DCP2RX7 purinoceptor: a therapeutic target for ameliorating the symptoms of duchenne muscular dystrophy. PLoS Med 2015, 12e1001888.

25983313

Toman P, Lien CF, Ahmad Z, Dietrich S, Smith JR, An Q, Molnár É, Pilkington GJ, Górecki DC, Tsibouklis J and Barbu ENanoparticles of alkylglyceryl-dextran-graft-poly(lactic acid) for drug delivery to the brain: Preparation and in vitro investigation. Acta Biomater 2015, 23250-62.

25700737

Young CN, Sinadinos A, Lefebvre A, Chan P, Arkle S, Vaudry D and Gorecki DCA novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90. Autophagy 2015, 11113-30.

25260053

Krasowska E, Zabłocki K, Górecki DC and Swinny JDAberrant location of inhibitory synaptic marker proteins in the hippocampus of dystrophin-deficient mice: implications for cognitive impairment in duchenne muscular dystrophy. PLoS One 2014, 9e108364.

23125840

Zablocka B, Goldspink PH, Goldspink G and Grecki DCMechano-Growth Factor: an important cog or a loose screw in the repair machinery. Front Endocrinol (Lausanne) 2012, 3131. doi.

23043099

Lien CF, Mohanta SK, Frontczak-Baniewicz M, Swinny J, Zablocka B and Gorecki DCAbsence of glial alpha-dystrobrevin causes abnormalities of the blood-brain barrier and progressive brain edema. J Biol Chem 2012

22553206

Xu XJ, Boumechache M, Robinson LE, Marschall V, Gorecki DC, Masin M and Murrell-Lagnado RDSplice variants of the P2X7 receptor reveal differential agonist dependence and functional coupling with pannexin-1. J Cell Sci 2012, 1253776-89. doi.

22409486

Lien CF, Molnr E, Toman P, Tsibouklis J, Pilkington GJ, Grecki DC and Barbu EIn vitro assessment of alkylglyceryl-functionalized chitosan nanoparticles as permeating vectors for the blood-brain barrier. Biomacromolecules 2012, 131067-73.

21838754

Masin M, Young C, Lim K, Barnes SJ, Xu XJ, Marschall V, Brutkowski W, Mooney ER, Gorecki DC and Murrell-Lagnado RExpression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: re-evaluation of P2X7 knockouts. Br J Pharmacol 2012, 165978-93. doi.

21807667

Birks SM, Danquah JO, King L, Vlasak R, Gorecki DC and Pilkington GJTargeting the GD3 acetylation pathway selectively induces apoptosis in glioblastoma. Neuro Oncol 2011, 13950-60.

21794079

Young CN, Brutkowski W, Lien CF, Arkle S, Lochmüller H, Zablocka K and Grecki DCP2X7 purinoceptor alterations in dystrophic mdx mouse muscles: relationship to pathology and potential target for treatment. J Cell Mol Med 2012, 161026-37. doi.

19766709

Beresewicz M, Majewska M, Makarewicz D, Vayro S, Zablocka B and Grecki DCChanges in the expression of insulin-like growth factor 1 variants in the postnatal brain development and in neonatal hypoxia-ischaemia. Int J Dev Neurosci 2010, 2891-7.

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