Réseau LARC - Neurosciences




Astrocyte and Vascular Niche

U1239 - DC2N

Research team



Université Rouen Normandie
Place Emile Blondel


Research interest:

Composition and main activity of the Team Astrocyte and Vascular Niche

Collaborations that have resulted in joint publications with other teams of the network:

Youssef ANOUAR / U1239 - Equipe Génomique fonctionnelle et physiopathologie neuronale et neuroendocrine
David VAUDRY / U1239 - Differenciation et Communication Neuronale et Neuroendocrine
Françis EUSTACHE / U1077

Main publications over the last few years:


Coly PM,, Perzo N,, Le Joncour V,, Lecointre C,, Schouft MT,, Desrues L,, Tonon MC,, Wurtz O,, Gandolfo P,, Castel H, and Morin F,Chemotactic G protein-coupled receptors control cell migration by repressing autophagosome biogenesis. Autophagy 2016, 122344-2362.


Lange M, Heutte N, Rigal O, Noal S, Kurtz JE, Lévy C, Allouache D, Rieux C, Lefel J, Clarisse B, Veyret C, Barthélémy P, Longato N, Castel H, Eustache F, Giffard B and Joly FDecline in Cognitive Function in Older Adults With Early-Stage Breast Cancer After Adjuvant Treatment. Oncologist 2016


Melot A, Labarre A, Vanhulle C, Rondeau S, Brasseur M, Gilard V, Castel H, Marret S and Proust FNeurodevelopmental long-term outcome in children with hydrocephalus requiring neonatal surgical treatment. Neurochirurgie 2016, 6294-9.


Clavier T, Besnier E, Lefevre-Scelles A, Lanfray D, Masmoudi O, Pelletier G, Castel H, Tonon MC and Compère VIncreased Hypothalamic Levels of Endozepines, Endogenous Ligands of Benzodiazepine Receptors, in a Rat Model of Sepsis. Shock 2016, 45653-9.


Joly F, Giffard B, Rigal O, De Ruiter MB, Small BJ, Dubois M, LeFel J, Schagen SB, Ahles TA, Wefel JS, Vardy JL, Pancré V, Lange M and Castel HImpact of Cancer and Its Treatments on Cognitive Function: Advances in Research From the Paris International Cognition and Cancer Task Force Symposium and Update Since 2012. J Pain Symptom Manage 2015, 50830-41.


Lecointre C, Desrues L, Joubert JE, Perzo N,, Guichet PO, Le Joncour V, Brulé C,, Chabbert M, Leduc R, Prézeau L, Laquerrière A, Proust F,, Gandolfo P, Morin F and Castel HSignaling switch of the urotensin II vasosactive peptide GPCR: prototypic chemotaxic mechanism in glioma. Oncogene 2015, 345080-94.


Dubois M, Le Joncour V, Tonon MC, Anouar Y, Proust F, Morin F, Gandolfo P, Joly F, Hilber P and Castel HEvaluation of the impact of the cancer therapy everolimus on the central nervous system in mice. PLoS One 2014, 9e113533.


Clavier T,,,, Tonon MC,,, Foutel A, Besnier E,,,, Lefevre-Scelles A, Morin F,,, Gandolfo P,,, Tuech JJ, Quillard M, Veber B, Dureuil B, Castel H,, and Compère V,,,Increased plasma levels of endozepines, endogenous ligands of benzodiazepine receptors, during systemic inflammation: a prospective observational study. Crit Care 2014, 18633.


Brulé C, Perzo N, Joubert JE, Sainsily X, Leduc R, Castel H and Prézeau LBiased signaling regulates the pleiotropic effects of the urotensin II receptor to modulate its cellular behaviors. FASEB J 2014, 285148-62.


Jarry M, Lecointre C, Malleval C, Desrues L, Schouft MT, Lejoncour V, Liger F, Lyvinec G, Joseph B, Loaëc N, Meijer L, Honnorat J, Gandolfo P and Castel HImpact of meriolins, a new class of cyclin-dependent kinase inhibitors, on malignant glioma proliferation and neo-angiogenesis. Neuro Oncol 2014, 161484-98.


Lévêque S, Derrey S, Castel H and Proust FThe Mini Supra-orbital Approach for Cerebral Aneurysm of the Anterior Portion of the Circle of Willis. Acta Neurochir Suppl 2014, 11921-4.


Pelé J, Moreau M, Abdi H, Rodien P, Castel H and Chabbert MComparative analysis of sequence covariation methods to mine evolutionary hubs: examples from selected GPCR families. Proteins 2014, 822141-56.


Bennani O, Derrey S, Langlois O, Castel H, Laquerriere A, Freger P and Proust FBrain metastasis from renal cell carcinoma. Neurochirurgie 2014, 6012-6.


Dubois M, Lapinte N, Villier V, Lecointre C, Roy V, Tonon MC, Gandolfo P, Joly F, Hilber P and Castel HChemotherapy-induced long-term alteration of executive functions and hippocampal cell proliferation: role of glucose as adjuvant. Neuropharmacology 2014, 79234-48.


Calvacante T, Derrey S, Curey S, Langlois O, Fréger P, Gérardin E, Castel H and Proust FDistal middle cerebral artery aneurysm: A proposition of microsurgical management. Neurochirurgie 2013, 59121-7.


Chevalier A, Dubois M, Le Joncour V, Dautrey S, Lecointre C, Romieu A, Renard PY, Castel H and Sabot CSynthesis, biological evaluation, and in vivo imaging of the first camptothecin-fluorescein conjugate. Bioconjug Chem 2013, 241119-33.


Joyard Y, Le Joncour V, Castel H, Diouf CB, Bischoff L, Papamicaël C, Levacher V, Vera P and Bohn PSynthesis and biological evaluation of a novel (99m)Tc labeled 2-nitroimidazole derivative as a potential agent for imaging tumor hypoxia. Bioorg Med Chem Lett 2013, 233704-8.


Lanfray D, Arthaud S, Ouellet J, Compère V, Do Rego JL, Leprince J, Lefranc B, Castel H, Bouchard C, Monge-Roffarello B, Richard D, Pelletier G, Vaudry H, Tonon MC and Morin FGliotransmission and brain glucose sensing: critical role of endozepines. Diabetes 2013, 62801-10.


Desrues L, Lefebvre T, Lecointre C, Schouft MT, Leprince J, Compère V, Morin F, Proust F, Gandolfo P, Tonon MC and Castel HDown-regulation of GABA(A) receptor via promiscuity with the vasoactive peptide urotensin II receptor. Potential involvement in astrocyte plasticity. PLoS One 2012, 7e36319.


Chabbert M, Castel H, Pele J, Deville J, Legendre R and Rodien PEvolution of class A G-protein-coupled receptors: implications for molecular modeling. Curr Med Chem 2012, 191110-8.


Lévêque S, Derrey S, Martinaud O, Gérardin E, Langlois O, Fréger P, Hannequin D, Castel H and Proust FSuperior interhemispheric approach for midline meningioma from the anterior cranial base. Neurochirurgie 2011, 57105-13.


Compère V, Lanfray D, Castel H, Morin F, Leprince J, Dureuil B, Vaudry H, Pelletier G and Tonon MCAcute food deprivation reduces expression of diazepam-binding inhibitor, the precursor of the anorexigenic octadecaneuropeptide ODN, in mouse glial cells. J Mol Endocrinol 2010, 44295-9.


Jarry M, Diallo M, Lecointre C, Desrues L, Tokay T, Chatenet D, Leprince J, Rossi O, Vaudry H, Tonon MC, Prézeau L, Castel H and Gandolfo PThe vasoactive peptides urotensin II and urotensin II-related peptide regulate astrocyte activity through common and distinct mechanisms: involvement in cell proliferation. Biochem J 2010, 428113-24.


Lefebvre T, Gonzalez BJ, Vaudry D, Desrues L, Falluel-Morel A, Aubert N, Fournier A, Tonon MC, Vaudry H and Castel HParadoxical effect of ethanol on potassium channel currents and cell survival in cerebellar granule neurons. J Neurochem 2009, 110976-89.

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