Neuropeptides, Neuronal death and Cell plasticity team
U1239 - Differenciation et Communication Neuronale et Neuroendocrine
Mechanisms involved in the development of the cerebellar cortex: The focus is on peptides controlling the proliferation, migration, differentiation and survival of cerebellar granule cells. Use of peptides and stem cells expressing peptides for the treatment of stroke: The focus is on the effect on peptides on the infarct volume, apoptosis, oxidative stress, inflammatory response and functional recovery related to brain ischemia. Investigation of the toxic effects of alcohol on the brain in a model of Alcohol Foetal Syndrom (AFS) and in a model of Binge Drinking: The focus is on the effect of peptides on oxidative stress, cell death and neurological deficits induced by ethanol exposure
Key words: Differentiation, Cerebellar granule cells, Binge Drinking
Collaborations that have resulted in joint publications with other teams of the network:Thierry CHARLIER / IRSET INSERM U1085/ Unversité de Rennes 1
Myriam BERNAUDIN / ISTCT- FRE2001
Denis VIVIEN / UMR-S U1237
Bruno GONZALEZ / U1245 (Dir T Frebourg)
Frédéric LANCIEN / UMR 6539
Helene CASTEL / U1239 - DC2N
David VAUDRY / PRIMACEN
Mickael NAASSILA / ERI 24
Pascal COSETTE / David VAUDRY / PISSARO
Jean-Claude DO REGO / SCAC
Pierre DECHELOTTE / INSERM UMR 1073
Darek GORECKI / IBBS
Main publications over the last few years:
. PACAP Protects the Adolescent and Adult Mice Brain from Ethanol Toxicity and Modulates Distinct Sets of Genes Regulating Similar Networks. Mol Neurobiol 2016
. Involvement of endogenous antioxidant systems in the protective activity of pituitary adenylate cyclase-activating polypeptide against hydrogen peroxide-induced oxidative damages in cultured rat astrocytes. J Neurochem 2016, 137: 913-30.
. Early Disruption of Extracellular Pleiotrophin Distribution Alters Cerebellar Neuronal Circuit Development and Function. Mol Neurobiol 2016, 53: 5203-16.
. Characterizations of a synthetic pituitary adenylate cyclase-activating polypeptide analog displaying potent neuroprotective activity and reduced in vivo cardiovascular side effects in a Parkinson's disease model. Neuropharmacology 2016, 108: 440-50.
. A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90. Autophagy 2015, 11: 113-30.
. Comparison of the deleterious effects of binge drinking-like alcohol exposure in adolescent and adult mice. J Neurochem 2015, 132: 629-41.
. Delayed pituitary adenylate cyclase-activating polypeptide delivery after brain stroke improves functional recovery by inducing m2 microglia/macrophage polarization. Stroke 2015, 46: 520-8.
. International Union of Basic and Clinical Pharmacology. XCII. Urotensin II, urotensin II-related peptide, and their receptor: from structure to function. Pharmacol Rev 2015, 67: 214-58.
. The octadecaneuropeptide ODN protects astrocytes against hydrogen peroxide-induced apoptosis via a PKA/MAPK-dependent mechanism. PLoS One 2012, 7: e42498. doi.
. Rescue of neuronal migration deficits in a mouse model of fetal Minamata disease by increasing neuronal Ca2+ spike frequency. Proc Natl Acad Sci U S A 2012, 109: 5057-62.
. Light stimuli control neuronal migration by altering of insulin-like growth factor 1 (IGF-1) signaling. Proc Natl Acad Sci U S A 2012, 109: 2630-5.
. Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR review 1. Br J Pharmacol 2012, 166: 4-17. doi.
. Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates the expression and the release of tissue plasminogen activator (tPA) in neuronal cells: involvement of tPA in the neuroprotective effect of PACAP. J Neurochem 2011, 119: 920-31. doi.
. Strategies to convert PACAP from a hypophysiotropic neurohormone into a neuroprotective drug. Curr Pharm Des 2011, 17: 1002-24.