Nutrition, Inflammation and dysfunction of the brain-gut axis
INSERM UMR 1073
Université de Rouen
The research of our group, integrated in the IRIB Institute, are mainly dedicated to the study of eating disorders, irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD). These pathologies share common features of intestinal inflammation and dysregulation of the gut-brain axis and offer great opportunities for innovative therapeutic strategies (immunonutrition, neurostimulation). Our projects explore the underlying mechanisms of these diseases from the molecular level to clinical trials. This broad range of research from the bench to the bedside is the result of our research strategy that brings together basic and clinical sciences, in a tight collaboration between laboratory scientists and health professionals. Our dynamic research team has an active research strategy which also drives the translation of research from the laboratory to patenting and creation of biotech company entrepreneurship (TargEdys).
The brain-gut axis
Key words: Nutrients, intestinal metabolism, eating disorders, intestinal inflammation, autoantibodies, neurostimulation, biomarkers
Collaborations that have resulted in joint publications with other teams of the network:Olivier BOYER / U1234 (PANTHER)
Youssef ANOUAR / U1239 - Equipe Génomique fonctionnelle et physiopathologie neuronale et neuroendocrine
David VAUDRY / U1239 - Differenciation et Communication Neuronale et Neuroendocrine
Pascal COSETTE / David VAUDRY / PISSARO
Jean-Claude DO REGO / SCAC
Main publications over the last few years:
. A role for intestinal TLR4-driven inflammatory response during activity-based anorexia. Sci Rep 2016, 6: 35813.
. Maintaining physical activity during refeeding improves body composition, intestinal hyperpermeability and behavior in anorectic mice. Sci Rep 2016, 6: 21887.
. Gut Commensal E. coli Proteins Activate Host Satiety Pathways following Nutrient-Induced Bacterial Growth. Cell Metab 2016, 23: 324-34.
. Enteral delivery of proteins enhances the expression of proteins involved in the cytoskeleton and protein biosynthesis in human duodenal mucosa. Am J Clin Nutr 2015, 102: 359-67.
. Dopamine release in the lateral hypothalamus is stimulated by α-MSH in both the anticipatory and consummatory phases of feeding. Psychoneuroendocrinology 2015, 56: 79-87.
. Impaired fasting pyloric compliance in gastroparesis and the therapeutic response to pyloric dilatation. Aliment Pharmacol Ther 2015, 41: 360-7.
. Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans. Nat Commun 2013, 4: 2685. doi.