Réseau LARC - Neurosciences




Microvascular Endothelium and Neonate Brain Lesions

U1245 (Dir T Frebourg)

Research team

Université de Rouen


Dr Bruno Gonzalez
«NeoVasc» Team, Microvascular Endothelium and Neonate Brain Lesions
Region-Inserm Team - ERI28
IRIB - Institute for Research and Innovation in Biomedicine
Bâtiment Recherche
Faculté de Médecine Pharmacie
22 Boulevard Gambetta


Key words: Cerebral palsy - prematurity - excitotoxicity - neuroprotection

Collaborations that have resulted in joint publications with other teams of the network:

Fabien Gosselet / EA 2465
Denis VIVIEN / UMR-S U1237
Vincent PREVOT / U1172
David VAUDRY / U1239 - Differenciation et Communication Neuronale et Neuroendocrine

Ongoing collaborations which have not yet conducted to joint publications:

Youssef ANOUAR / U1239 - Equipe Génomique fonctionnelle et physiopathologie neuronale et neuroendocrine

Main publications over the last few years:


Henry VJ, Lecointre M, Laudenbach V, Ali C, Macrez R, Jullienne A, Beresowski V, Carmeliet P, Vivien D, Marret S, Gonzalez BJ and Leroux PHigh t-PA release by neonate brain microvascular endothelial cells under glutamate exposure affects neuronal fate. Neurobiol Dis 2012


El Ghazi F, Desfeux A, Brasse-Lagnel C, Roux C, Lesueur C, Mazur D, Remy-Jouet I, Richard V, Jégou S, Laudenbach V, Marret S, Bekri S, Prevot V and Gonzalez BJNO-dependent protective effect of VEGF against excitotoxicity on layer VI of the developing cerebral cortex. Neurobiol Dis 2012, 45871-86.


Friocourt G, Marcorelles P, Saugier-Veber P, Quille ML, Marret S and Laquerrière ARole of cytoskeletal abnormalities in the neuropathology and pathophysiology of type I lissencephaly. Acta Neuropathol 2011, 121149-70.


Chévrier M, Brakch N, Céline L, Genty D, Ramdani Y, Moll S, Djavaheri-Mergny M, Brasse-Lagnel C, Annie Laquerrière AL, Barbey F and Bekri SAutophagosome maturation is impaired in Fabry disease. Autophagy 2010, 6589-99.


Sentilhes L, Michel C, Lecourtois M, Catteau J, Bourgeois P, Laudenbach V, Marret S and Laquerrière AVascular endothelial growth factor and its high-affinity receptor (VEGFR-2) are highly expressed in the human forebrain and cerebellum during development. J Neuropathol Exp Neurol 2010, 69111-28.


Desfeux A, El Ghazi F, Jégou S, Legros H, Marret S, Laudenbach V and Gonzalez BJDual effect of glutamate on GABAergic interneuron survival during cerebral cortex development in mice neonates. Cereb Cortex 2010, 201092-108.


Legros H, Launay S, Roussel BD, Marcou-Labarre A, Calbo S, Catteau J, Leroux P, Boyer O, Ali C, Marret S, Vivien D and Laudenbach VNewborn- and adult-derived brain microvascular endothelial cells show age-related differences in phenotype and glutamate-evoked protease release. J Cereb Blood Flow Metab 2009, 291146-58.


Doyle LW, Crowther CA, Middleton P, Marret S and Rouse DMagnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus. Cochrane Database Syst Rev 2009CD004661.


Aubert N, Vaudry D, Falluel-Morel A, Desfeux A, Fisch C, Ancian P, de Jouffrey S, Le Bigot JF, Couvineau A, Laburthe M, Fournier A, Laudenbach V, Vaudry H and Gonzalez BJPACAP prevents toxicity induced by cisplatin in rat and primate neurons but not in proliferating ovary cells: involvement of the mitochondrial apoptotic pathway. Neurobiol Dis 2008, 3266-80.


Larroque B, Ancel PY, Marret S, Marchand L, André M, Arnaud C, Pierrat V, Rozé JC, Messer J, Thiriez G, Burguet A, Picaud JC, Bréart G and Kaminski M; EPIPAGE Study groupNeurodevelopmental disabilities and special care of 5-year-old children born before 33 weeks of gestation (the EPIPAGE study): a longitudinal cohort study. Lancet 2008, 371813-20.


Zhokhov SS, Desfeux A, Aubert N, Falluel-Morel A, Fournier A, Laudenbach V, Vaudry H and Gonzalez BJBax siRNA promotes survival of cultured and allografted granule cell precursors through blockade of caspase-3 cleavage. Cell Death Differ 2008, 151042-53.

Conçu par Alexis Lebon © 2008-2018  | Mentions légales