Microvascular Endothelium and Neonate Brain Lesions
U1245 (Dir T Frebourg)
Université de Rouen
Key words: Cerebral palsy - prematurity - excitotoxicity - neuroprotection
Collaborations that have resulted in joint publications with other teams of the network:Fabien Gosselet / EA 2465
Denis VIVIEN / UMR-S U1237
Vincent PREVOT / U1172
David VAUDRY / U1239 - Differenciation et Communication Neuronale et Neuroendocrine
David VAUDRY / PRIMACEN
Ongoing collaborations which have not yet conducted to joint publications:Youssef ANOUAR / U1239 - Equipe Génomique fonctionnelle et physiopathologie neuronale et neuroendocrine
Pascal COSETTE / David VAUDRY / PISSARO
Main publications over the last few years:
. High t-PA release by neonate brain microvascular endothelial cells under glutamate exposure affects neuronal fate. Neurobiol Dis 2012
. NO-dependent protective effect of VEGF against excitotoxicity on layer VI of the developing cerebral cortex. Neurobiol Dis 2012, 45: 871-86.
. Role of cytoskeletal abnormalities in the neuropathology and pathophysiology of type I lissencephaly. Acta Neuropathol 2011, 121: 149-70.
. Autophagosome maturation is impaired in Fabry disease. Autophagy 2010, 6: 589-99.
. Vascular endothelial growth factor and its high-affinity receptor (VEGFR-2) are highly expressed in the human forebrain and cerebellum during development. J Neuropathol Exp Neurol 2010, 69: 111-28.
. Dual effect of glutamate on GABAergic interneuron survival during cerebral cortex development in mice neonates. Cereb Cortex 2010, 20: 1092-108.
. Newborn- and adult-derived brain microvascular endothelial cells show age-related differences in phenotype and glutamate-evoked protease release. J Cereb Blood Flow Metab 2009, 29: 1146-58.
. Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus. Cochrane Database Syst Rev 2009: CD004661.
. PACAP prevents toxicity induced by cisplatin in rat and primate neurons but not in proliferating ovary cells: involvement of the mitochondrial apoptotic pathway. Neurobiol Dis 2008, 32: 66-80.
. Neurodevelopmental disabilities and special care of 5-year-old children born before 33 weeks of gestation (the EPIPAGE study): a longitudinal cohort study. Lancet 2008, 371: 813-20.
. Bax siRNA promotes survival of cultured and allografted granule cell precursors through blockade of caspase-3 cleavage. Cell Death Differ 2008, 15: 1042-53.