Groupe de Recherche sur l'Alcool et les Pharmacodépendances
Université de Picardie
Key words: alcoholism; addiction; neuropharmacology, pharmacogenetics; epigenetics; relapse; synaptic plasticity; hippocampus; adolescence; fetal alcohol; binge drinking; brain imaging; neuropsychology; behavioural sensitization; self-administration; alcohol hepatitis; alcoholic liver disease;
Collaborations that have resulted in joint publications with other teams of the network:David VAUDRY / U1239 - Differenciation et Communication Neuronale et Neuroendocrine
Main publications over the last few years:
. Increase of KCC2 in hippocampal synaptic plasticity disturbances after perinatal ethanol exposure. Addict Biol 2016
. Hepatocyte SLAMF3 reduced specifically the multidrugs resistance protein MRP-1 and increases HCC cells sensitization to anti-cancer drugs. Oncotarget 2016, 7: 32493-503.
. Resistance to ethanol sensitization is associated with a loss of synaptic plasticity in the hippocampus. Synapse 2016
. Altered white matter integrity in whole brain and segments of corpus callosum, in young social drinkers with binge drinking pattern. Addict Biol 2015
. Two Binges of Ethanol a Day Keep the Memory Away in Adolescent Rats: Key Role for GLUN2B Subunit. Int J Neuropsychopharmacol 2015, 19: pyv087.
. Positive and negative metacognitions about alcohol use among university students: Psychometric properties of the PAMS and NAMS French versions. Drug Alcohol Depend 2015, 153: 78-85.
. The Class I-Specific HDAC Inhibitor MS-275 Decreases Motivation to Consume Alcohol and Relapse in Heavy Drinking Rats. Int J Neuropsychopharmacol 2015, 18: pyv029.
. Basal anxiety negatively correlates with vulnerability to ethanol-induced behavioral sensitization in DBA/2J mice: modulation by diazepam. Alcohol Clin Exp Res 2015, 39: 45-54.
. Aberrant NMDA-dependent LTD after perinatal ethanol exposure in young adult rat hippocampus. Hippocampus 2015, 25: 912-23.
. Comparison of the deleterious effects of binge drinking-like alcohol exposure in adolescent and adult mice. J Neurochem 2015, 132: 629-41.
. Memantine reduces alcohol drinking but not relapse in alcohol-dependent rats. Addict Biol 2015, 20: 890-901.
. The histone deacetylase inhibitor sodium butyrate decreases excessive ethanol intake in dependent animals. Addict Biol 2015, 20: 676-89.
. Light alcohol intake during adolescence induces alcohol addiction in a neurodevelopmental model of schizophrenia. Addict Biol 2015, 20: 490-9.
. Endogenous nitric oxide but not exogenous no-donor S-nitroprussiate facilitates NMDA excitation in spontaneous rhythmic neonatal rat brainstem slice. Brain Res 2014, 1543: 9-16.
. Deciphering the relationship between vulnerability to ethanol-induced behavioral sensitization and ethanol consumption in outbred mice. Addict Biol 2014, 19: 210-24.
. Chronic ethanol exposure during development: disturbances of breathing and adaptation. Respir Physiol Neurobiol 2013, 189: 250-60.
. Blockade of ethanol-induced behavioral sensitization by sodium butyrate: descriptive analysis of gene regulations in the striatum. Alcohol Clin Exp Res 2013, 37: 1143-53.
. Brain-derived neurotrophic factor mediates the suppression of alcohol self-administration by memantine. Addict Biol 2014, 19: 758-69.
. The adenosine A2A receptor agonist CGS 21680 decreases ethanol self-administration in both non-dependent and dependent animals. Addict Biol 2013, 18: 812-25.
. Alcohol intoxications during adolescence increase motivation for alcohol in adult rats and induce neuroadaptations in the nucleus accumbens. Neuropharmacology 2013, 67: 521-31.
. Expression of ethanol-induced behavioral sensitization is associated with alteration of chromatin remodeling in mice. PLoS One 2012, 7: e47527. doi.
. Chronic and Intermittent Exposure to Alcohol Vapors: A New Model of Alcohol-Induced Osteopenia in the Rat. Alcohol Clin Exp Res 2012
. "Beetrack": a software for 2D open field locomotion analysis in honey bees. J Neurosci Methods 2012, 207: 211-7.
. Glucocorticoids plus N-acetylcysteine in severe alcoholic hepatitis. N Engl J Med 2011, 365: 1781-9.
. Fluoxetine, desipramine, and the dual antidepressant milnacipran reduce alcohol self-administration and/or relapse in dependent rats. Neuropsychopharmacology 2011, 36: 1518-30.
. Noninvasive diagnosis of large esophageal varices by Fibroscan: strong influence of the cirrhosis etiology. Alcohol Clin Exp Res 2010, 34: 1146-53.
. Lack of association between tumour necrosis factor receptor types 1 and 2 gene polymorphism and severe acute alcoholic hepatitis. Eur J Gastroenterol Hepatol 2010, 22: 794-800.
. The genetics of alcoholic liver disease: better patient group definition is required. Am J Gastroenterol 2009, 104: 1848-9.
. Predicting the effect of naltrexone and acamprosate in alcohol-dependent patients using genetic indicators. Addict Biol 2009, 14: 328-37.
. Effects of prenatal and postnatal maternal ethanol on offspring response to alcohol and psychostimulants in long evans rats. Neuroscience 2009, 161: 427-40.
. Ethanol-sensitive brain regions in rat and mouse: a cartographic review, using immediate early gene expression. Alcohol Clin Exp Res 2009, 33: 945-69.
. Perinatal alcohol exposure in rat induces long-term depression of respiration after episodic hypoxia. Am J Respir Crit Care Med 2009, 179: 608-14.
. Involvement of A2A receptors in anxiolytic, locomotor and motivational properties of ethanol in mice. Genes Brain Behav 2008, 7: 887-98.
. Long-term alterations in vulnerability to addiction to drugs of abuse and in brain gene expression after early life ethanol exposure. Neuropharmacology 2008, 55: 1199-211.
. A haplotype of the DRD1 gene is associated with alcohol dependence. Alcohol Clin Exp Res 2008, 32: 567-72.
. The -308 TNFalpha gene polymorphism in severe acute alcoholic hepatitis: identification of a new susceptibility marker. Alcohol Clin Exp Res 2008, 32: 822-8.
. Blunted response to low oxygen of rat respiratory network after perinatal ethanol exposure: involvement of inhibitory control. J Physiol 2008, 586: 1413-27.
. The lack of CB1 receptors prevents neuroadapatations of both NMDA and GABA(A) receptors after chronic ethanol exposure. J Neurochem 2007, 102: 741-52.
. Early chronic ethanol exposure in rats disturbs respiratory network activity and increases sensitivity to ethanol. J Physiol 2006, 576: 297-307.
. CB1 receptor knockout mice display reduced ethanol-induced conditioned place preference and increased striatal dopamine D2 receptors. Neuropsychopharmacology 2005, 30: 339-49.