Réseau LARC - Neurosciences




Groupe de Recherche sur l'Alcool et les Pharmacodépendances

ERI 24

Research team

Université de Picardie


Universite de Picardie Jules Verne
Centre Universitaire de Recherche en Sante (CURS)
Chemin du Thil
80025 Amiens cedex 1


Key words: alcoholism; addiction; neuropharmacology, pharmacogenetics; epigenetics; relapse; synaptic plasticity; hippocampus; adolescence; fetal alcohol; binge drinking; brain imaging; neuropsychology; behavioural sensitization; self-administration; alcohol hepatitis; alcoholic liver disease;

Collaborations that have resulted in joint publications with other teams of the network:

David VAUDRY / U1239 - Differenciation et Communication Neuronale et Neuroendocrine

Main publications over the last few years:


Silvestre de Ferron B, Vilpoux C, Kervern M, Robert A, Antol J, Naassila M and Pierrefiche OIncrease of KCC2 in hippocampal synaptic plasticity disturbances after perinatal ethanol exposure. Addict Biol 2016


Fouquet G, Debuysscher V, Ouled-Haddou H, Eugenio MS, Demey B, Singh AR, Ossart C, Al Bagami M, Regimbeau JM, Nguyen-Khac E,, Naassila M, Marcq I and Bouhlal H,Hepatocyte SLAMF3 reduced specifically the multidrugs resistance protein MRP-1 and increases HCC cells sensitization to anti-cancer drugs. Oncotarget 2016, 732493-503.


Coune F, Silvestre de Ferron B, González-Marín MC, Antol J, Naassila M and Pierrefiche OResistance to ethanol sensitization is associated with a loss of synaptic plasticity in the hippocampus. Synapse 2016


Smith KW,, Gierski F, Andre J, Dowell NG, Cercignani M, Naassila M and Duka T,Altered white matter integrity in whole brain and segments of corpus callosum, in young social drinkers with binge drinking pattern. Addict Biol 2015


Silvestre de Ferron B, Bennouar KE, Kervern M, Alaux-Cantin S, Robert A, Rabiant K, Antol J, Naassila M and Pierrefiche OTwo Binges of Ethanol a Day Keep the Memory Away in Adolescent Rats: Key Role for GLUN2B Subunit. Int J Neuropsychopharmacol 2015, 19 pyv087.


Gierski F, Spada MM, Fois E, Picard A, Naassila M and Van der Linden MPositive and negative metacognitions about alcohol use among university students: Psychometric properties of the PAMS and NAMS French versions. Drug Alcohol Depend 2015, 15378-85.


Jeanblanc J, Lemoine S, Jeanblanc V, Alaux-Cantin S and Naassila MThe Class I-Specific HDAC Inhibitor MS-275 Decreases Motivation to Consume Alcohol and Relapse in Heavy Drinking Rats. Int J Neuropsychopharmacol 2015, 18 pyv029.


Botia B, Legastelois R, Houchi H and Naassila MBasal anxiety negatively correlates with vulnerability to ethanol-induced behavioral sensitization in DBA/2J mice: modulation by diazepam. Alcohol Clin Exp Res 2015, 3945-54.


Kervern M, Silvestre de Ferron B, Alaux-Cantin S, Fedorenko O, Antol J, Naassila M and Pierrefiche OAberrant NMDA-dependent LTD after perinatal ethanol exposure in young adult rat hippocampus. Hippocampus 2015, 25912-23.


Lacaille H, Duterte-Boucher D, Liot D, Vaudry H, Naassila M and Vaudry DComparison of the deleterious effects of binge drinking-like alcohol exposure in adolescent and adult mice. J Neurochem 2015, 132629-41.


Alaux-Cantin S, Buttolo R, Houchi H, Jeanblanc J and Naassila MMemantine reduces alcohol drinking but not relapse in alcohol-dependent rats. Addict Biol 2015, 20890-901.


Simon-O'Brien E, Alaux-Cantin S, Warnault V, Buttolo R, Naassila M and Vilpoux CThe histone deacetylase inhibitor sodium butyrate decreases excessive ethanol intake in dependent animals. Addict Biol 2015, 20676-89.


Jeanblanc J, Balguerie K, Coune F, Legastelois R, Jeanblanc V and Naassila MLight alcohol intake during adolescence induces alcohol addiction in a neurodevelopmental model of schizophrenia. Addict Biol 2015, 20490-9.


Pierrefiche O and Naassila MEndogenous nitric oxide but not exogenous no-donor S-nitroprussiate facilitates NMDA excitation in spontaneous rhythmic neonatal rat brainstem slice. Brain Res 2014, 15439-16.


Legastelois R, Botia B, Coune F, Jeanblanc J and Naassila MDeciphering the relationship between vulnerability to ethanol-induced behavioral sensitization and ethanol consumption in outbred mice. Addict Biol 2014, 19210-24.


Dubois CJ, Kervern M, Naassila M and Pierrefiche OChronic ethanol exposure during development: disturbances of breathing and adaptation. Respir Physiol Neurobiol 2013, 189250-60.


Legastelois R, Botia B and Naassila MBlockade of ethanol-induced behavioral sensitization by sodium butyrate: descriptive analysis of gene regulations in the striatum. Alcohol Clin Exp Res 2013, 371143-53.


Jeanblanc J, Coune F, Botia B and Naassila MBrain-derived neurotrophic factor mediates the suppression of alcohol self-administration by memantine. Addict Biol 2014, 19758-69.


Houchi H, Persyn W, Legastelois R and Naassila MThe adenosine A2A receptor agonist CGS 21680 decreases ethanol self-administration in both non-dependent and dependent animals. Addict Biol 2013, 18812-25.


Alaux-Cantin S, Warnault V, Legastelois R, Botia B, Pierrefiche O, Vilpoux C and Naassila MAlcohol intoxications during adolescence increase motivation for alcohol in adult rats and induce neuroadaptations in the nucleus accumbens. Neuropharmacology 2013, 67521-31.


Botia B, Legastelois R, Alaux-Cantin S and Naassila MExpression of ethanol-induced behavioral sensitization is associated with alteration of chromatin remodeling in mice. PLoS One 2012, 7e47527. doi.


Maurel DB, Jaffré C, Simon O'Brien E, Tournier CC, Houchi H, Benhamou CL and Naassila MChronic and Intermittent Exposure to Alcohol Vapors: A New Model of Alcohol-Induced Osteopenia in the Rat. Alcohol Clin Exp Res 2012


Sokolowski MB, Moine M and Naassila M"Beetrack": a software for 2D open field locomotion analysis in honey bees. J Neurosci Methods 2012, 207211-7.


Nguyen-Khac E, Thevenot T, Piquet MA, Benferhat S, Goria O, Chatelain D, Tramier B, Dewaele F, Ghrib S, Rudler M, Carbonell N, Tossou H, Bental A, Bernard-Chabert B and Dupas JL; AAH-NAC Study GroupGlucocorticoids plus N-acetylcysteine in severe alcoholic hepatitis. N Engl J Med 2011, 3651781-9.


Simon O'Brien E, Legastelois R, Houchi H, Vilpoux C, Alaux-Cantin S, Pierrefiche O, André E and Naassila MFluoxetine, desipramine, and the dual antidepressant milnacipran reduce alcohol self-administration and/or relapse in dependent rats. Neuropsychopharmacology 2011, 361518-30.


Nguyen-Khac E, Saint-Leger P, Tramier B, Coevoet H, Capron D and Dupas JLNoninvasive diagnosis of large esophageal varices by Fibroscan: strong influence of the cirrhosis etiology. Alcohol Clin Exp Res 2010, 341146-53.


Nguyen-Khac E, Houchi H, Daoust M, Dupas JL and Naassila MLack of association between tumour necrosis factor receptor types 1 and 2 gene polymorphism and severe acute alcoholic hepatitis. Eur J Gastroenterol Hepatol 2010, 22794-800.


Nguyen-Khac E, Houchi H, Daoust M and Naassïla MThe genetics of alcoholic liver disease: better patient group definition is required. Am J Gastroenterol 2009, 1041848-9.


Ooteman W, Naassila M, Koeter MW, Verheul R, Schippers GM, Houchi H, Daoust M and van den Brink WPredicting the effect of naltrexone and acamprosate in alcohol-dependent patients using genetic indicators. Addict Biol 2009, 14328-37.


Barbier E, Houchi H, Warnault V, Pierrefiche O, Daoust M and Naassila MEffects of prenatal and postnatal maternal ethanol on offspring response to alcohol and psychostimulants in long evans rats. Neuroscience 2009, 161427-40.


Vilpoux C, Warnault V, Pierrefiche O, Daoust M and Naassila MEthanol-sensitive brain regions in rat and mouse: a cartographic review, using immediate early gene expression. Alcohol Clin Exp Res 2009, 33945-69.


Kervern M, Dubois C, Naassila M, Daoust M and Pierrefiche OPerinatal alcohol exposure in rat induces long-term depression of respiration after episodic hypoxia. Am J Respir Crit Care Med 2009, 179608-14.


Houchi H, Warnault V, Barbier E, Dubois C, Pierrefiche O, Ledent C, Daoust M and Naassila MInvolvement of A2A receptors in anxiolytic, locomotor and motivational properties of ethanol in mice. Genes Brain Behav 2008, 7887-98.


Barbier E, Pierrefiche O, Vaudry D, Vaudry H, Daoust M and Naassila MLong-term alterations in vulnerability to addiction to drugs of abuse and in brain gene expression after early life ethanol exposure. Neuropharmacology 2008, 551199-211.


Batel P, Houchi H, Daoust M, Ramoz N, Naassila M and Gorwood PA haplotype of the DRD1 gene is associated with alcohol dependence. Alcohol Clin Exp Res 2008, 32567-72.


Nguyen-Khac E, Houchi H, Daoust M, Dupas JL and Naassila MThe -308 TNFalpha gene polymorphism in severe acute alcoholic hepatitis: identification of a new susceptibility marker. Alcohol Clin Exp Res 2008, 32822-8.


Dubois C, Houchi H, Naassila M, Daoust M and Pierrefiche OBlunted response to low oxygen of rat respiratory network after perinatal ethanol exposure: involvement of inhibitory control. J Physiol 2008, 5861413-27.


Warnault V, Houchi H, Barbier E, Pierrefiche O, Vilpoux C, Ledent C, Daoust M and Naassila MThe lack of CB1 receptors prevents neuroadapatations of both NMDA and GABA(A) receptors after chronic ethanol exposure. J Neurochem 2007, 102741-52.


Dubois C, Naassila M, Daoust M and Pierrefiche OEarly chronic ethanol exposure in rats disturbs respiratory network activity and increases sensitivity to ethanol. J Physiol 2006, 576297-307.


Houchi H, Babovic D, Pierrefiche O, Ledent C, Daoust M and Naassila MCB1 receptor knockout mice display reduced ethanol-induced conditioned place preference and increased striatal dopamine D2 receptors. Neuropsychopharmacology 2005, 30339-49.

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